Which organ is most sensitive to the absence of glucose?

Brain is the organ that is most sensitive to the absence of glucose in the blood. The glucose is needed by the neurons in the brain to carry out their functions. The neurons when deprived of glucose, start to slow down and die out of exhaustion. The lack of glucose can cause symptoms of hypoglycemia, wherein a person starts to experience hallucinations and suffers from excruciating pain in the joints of the bones.  

The correct answer is brain.  

In the lacking of glucose in the blood, brain is one of the most sensitive organs. Glucose is important for the neurons into the organ of brain in order to perform the functions. You can die of exhaustion in lack of glucose. Its major sign is hypoglycemia.

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