When there are only a few surviving individuals of a species, the species is vunerable to extinction because there is little if any on which natural selection can act?

i believe the correct answer from the choices listed above is the first option. the scientists need to look at the   validity of data, claims, hypotheses, and observations before  developing an argument. they base their arguments on facts that are present and they make sure they have proofs. 

explanation:

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme