Aco-worker complains of numbness and tingling in the hands when typing. you suspect carpal tunnel syndrome which affects the nerve.

You are studying a protein that you call protein x. there is an aspartic acid at a key position in protein x which is important in the folding and stabilization of that protein. if this aspartic acid is changed to a different amino acid, which type of amino acid substitutions is most likely to allow the protein to fold normally?