What is a meme? please tell me

Where is the above note played on the guitar? open second string open third string second string, first fret third string, second fret

He fields of graphic design and animation changed completely in a very short period of time in the late twentieth century. nearly everything that was once drawn by hand on a drafting table is now done on a computer screen. what are some of the advantages of this transition to digital techniques? are there any disadvantages? what are some of the skills that today’s graphic designers and animation engineers have that earlier ones did not? are there any skills that have been lost in the move to digital techniques?

Who is depicted in the image below?