Which goes where? Please help

Which is likely the most serious problem associated with an epidemic? 1. there are sometimes no cures to the diseases that spread. 2. people often die from the diseases that spread. 3. there are usually no ways to prevent people from getting ill. 4. people often don’t know they have a disease.

What was the result on the u. s. economy because of the major changes in atlantic shipping prior to and during the war of 1812?

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